Mercapturate Metabolism of 4-Hydroxy-2-Nonenal in Rat and Human Cerebrum
نویسندگان
چکیده
منابع مشابه
Mercapturate metabolism of 4-hydroxy-2-nonenal in rat and human cerebrum.
4-Hydroxy-2-nonenal (HNE), a potent toxin formed in the brain from oxidation of polyunsaturated fatty acids, is increased in Alzheimer disease (AD), where it is a proposed effector of amyloid beta peptide-mediated neurotoxicity. Detoxification of HNE via the mercapturic acid pathway (MAP) is the primary means by which other organs, such as liver, limit its toxic effects. Here we examined the di...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2003
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/62.2.146